Christianity was originally a sect of Second Temple Judaism, but the two religions diverged in the first century. The differences between Christianity and Judaism originally centered on whether Jesus was the Jewish Messiah but eventually became irreconcilable. Major differences between the two faiths include the nature of the Messiah, of atonement and sin, the status of God's commandments to Israel, and perhaps most significantly of the nature of God himself. Due to these differences, Judaism traditionally regards Christianity as Shituf or worship of the God of Israel which is not monotheistic. Christianity has traditionally regarded Judaism as obsolete with the invention of Christianity and Jews as a people replaced by the Church, though a Christian belief in dual-covenant theology emerged as a phenomenon following Christian reflection on how their theology influenced the Nazi Holocaust.

Since the time of the Middle Ages, the Catholic Church upheld the Constitutio pro Judæis (Formal Statement on the Jews), which stated

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           We decree that no Christian shall use violence to force them to be baptized, so long as they are unwilling and refuse. ...               Without the judgment of the political authority of the land, no Christian shall presume to wound them or kill them or                   rob them of  their money or change the good customs that they have thus far enjoyed in the place where they live."

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Until their emancipation in the late 18th and the 19th century, Jews in Christian lands were subject to humiliating legal restrictions and limitations. They included provisions requiring Jews to wear specific and identifying clothing such as the Jewish hat and the yellow badge, restricting Jews to certain cities and towns or in certain parts of towns (ghettos), and forbidding Jews to enter certain trades (for example selling new clothes in medieval Sweden). Disabilities also included special taxes levied on Jews, exclusion from public life, restraints on the performance of religious ceremonies, and linguistic censorship. Some countries went even further and completely expelled Jews, for example, England in 1290 (Jews were readmitted in 1655) and Spain in 1492 (readmitted in 1868). The first Jewish settlers in North America arrived in the Dutch colony of New Amsterdam in 1654; they were forbidden to hold public office, open a retail shop, or establish a synagogue. When the colony was seized by the British in 1664 Jewish rights remained unchanged, but by 1671 Asser Levy was the first Jew to serve on a jury in North America. In 1791, Revolutionary France was the first country to abolish disabilities altogether, followed by Prussia in 1848. Emancipation of the Jews in the United Kingdom was achieved in 1858 after an almost 30-year struggle championed by Isaac Lyon Goldsmid with the ability of Jews to sit in parliament with the passing of the Jews Relief Act 1858. The newly created German Empire in 1871 abolished Jewish disabilities in Germany, which were reinstated in the Nuremberg Laws in 1935.

Jewish life in Christian lands was marked by frequent blood libels, expulsions, forced conversions and massacres. Religious prejudice was an underlying source against Jews in Europe. Christian rhetoric and antipathy towards Jews developed in the early years of Christianity and was reinforced by ever increasing anti-Jewish measures over the ensuing centuries. The action taken by Christians against Jews included acts of violence, and murder culminating in the Holocaust.:21:169 These attitudes were reinforced by Christian preaching, in art and popular teaching for two millennia which expressed contempt for Jews, as well as statutes which were designed to humiliate and stigmatise Jews. The Nazi Party was known for its persecution of Christian Churches; many of them, such as the Protestant Confessing Church and the Catholic Church, as well as Quakers and Jehovah's Witnesses, aided and rescued Jews who were being targeted by the antireligious régime.

The attitude of Christians and Christian Churches toward the Jewish people and Judaism have changed in a mostly positive direction since World War II. Pope John Paul II and the Catholic Church have "upheld the Church's acceptance of the continuing and permanent election of the Jewish people" as well as a reaffirmation of the covenant between God and the Jews. In December 2015, the Vatican released a 10,000-word document that, among other things, stated that Catholics should work with Jews to fight antisemitism.